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Journal: BMC Cancer
Article Title: Functional analysis and verification of GYG2 in oncolytic virus-infected glioma
doi: 10.1186/s12885-025-15407-y
Figure Lengend Snippet: Down-regulating GYG2 has antitumor effect in vitro. ( A ) HPA data indicated that GYG2 protein expression significantly increases in glioma tumor samples compared to normal. B GYG2 qPCR mRNA analysis of glioma clinical tissues (n = 30) compared to normal (n = 20). C GYG2 qPCR mRNA analysis of U87MG and U251 cells. D GYG2 mRNA expression in U87MG and U251 cells with transfection of siRNAs. E-F Cell growth in U87MG and U251 cells transfected sh-GYG2 or sh-NC. G Cell apoptotic rate in U87MG and U251 cells transfected sh-GYG2 or sh-NC. H Caspase-3 activity in U87MG and U251 cells transfected sh-GYG2 or sh-NC.*** p < 0.001
Article Snippet: The study utilized two glioma cell lines: U87MG and
Techniques: In Vitro, Expressing, Transfection, Activity Assay
Journal: BMC Cancer
Article Title: Functional analysis and verification of GYG2 in oncolytic virus-infected glioma
doi: 10.1186/s12885-025-15407-y
Figure Lengend Snippet: VSV-M51 infection promotes glioma cell apoptosis by downregulating GYG2. Glioma cells were transfected with ov-GYG2 or vector plasmids and then treated with VSV-M51. ( A-B) Cell growth in U87MG and U251 cells. C Caspase-3 activity in U87MG and U251 cells. ( D-E) Cell apoptotic rate in U87MG and U251 cells. *** p < 0.001, compared with UV-VSV-M51 group; #p < 0.05, compared with VSV-M51+Vector group
Article Snippet: The study utilized two glioma cell lines: U87MG and
Techniques: Infection, Transfection, Plasmid Preparation, Activity Assay